Handbook of Basic Pharmacokinetics

"Overall, the book is successful in explaining complicated pharmacokinetics concepts in a manner that is easy to understand and can be quickly referenced."

—Melissa Ranieri, PharmD
Temple University School of Pharmacy

Designed to distill the principles and facts of pharmacokinetics effectively, the Handbook of Basic Pharmacokinetics . . . Including Clinical Applications is a great resource on the most relevant scientific information for students, researchers, and practitioners. Readers will find the book current, accurate, comprehensive, and clinically useful. A chapter titled "Pharmacogenetics and Pharmacogenomics" addresses the influence of genetic constitution on the enzymes and transporters that affect drug disposition and action.

Table of Contents
• Definitions and Glossary
• The LADMER System: Drug Liberation, Absorption, Distribution, Metabolism, Elimination, and Response
• Organs, Tissues, Cells, and Organelles
• Cell Membranes — Structure, Functions, and Properties
• Drug Receptor Interactions
• Absorption/Transport Mechanisms
• pKa and Degree of Ionization
• Lipid/Water Partition Coefficient
• Physico-Chemical Factors Altering Biological Performance of Drugs
• Biopharmaceutical Data of the Gastrointestinal Tract
• Fluid Compartments and Circulatory System (Blood and Lymph)
• Binding of Drugs to Biological Material
• Drug Biotransformation
• Compartment Models
• Determination of Rate Constants
• Volume of Distribution and Distribution Coefficient
• Excretion and Clearance of Drugs
• Urinary and Biliary Recycling
• Cumulative Urinary Excretion
• Area Under the Blood Level–Time Curve
• Pharmacokinetics of Single Dose Administration
• Pharmacokinetics of Multiple Dosing
• Compartment Model Independent Analysis
• Pediatric Pharmacokinetics
• Drug Dosage in Elderly Patients
• Drug Dosage in Obese Patients
• Drug Disposition in Pregnancy
• Dosage Regimen Design
• Drug Monitoring and Dose Adjustment
• Physiological and Pathological Factors Influencing Drug Response
• First Dose Size in Man
• Forensic Pharmacokinetics
• Nonlinear Pharmacokinetics
• Curve Fitting
• Correlation of Clinical Response with Drug Disposition
• Bioavailability and Bioequivalence
• Body Surface Area
• Extracorporeal Methods of Drug Removal
• Pharmacogenetics and Pharmacogenomics