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After her teenage daughter Mia falls in with the wrong crowd, Dr Billie Green decides it's time to leave the city and return home to far western NSW. When an opportunity to pursue her childhood dream of joining the Flying Doctor Service comes along, she jumps at the chance. Flight nurse Daphne Prince – who is thrilled to have another woman join the otherwise male crew – and their handsome new boss, Morgan Blake, instantly make her feel welcome.

Just out of town, drought-stricken grazier Soretta Byrnes has been struggling to make ends meet and in desperation has opened her station house to boarders. Tempted by its faded splendour and beautiful outback setting, Billie, Mia and Daphne decide to move in and the four of them are soon joined by eccentric eighty-year-old Lorna Lamerton.

The unlikely housemates are cautious at first, but soon they are offering each other frank advice and staunch support as they tackle medical emergencies, romantic adventures and the challenges of growing up and getting older. But when one of their lives is threatened, the strong friendship they have forged will face the ultimate test . . .