Littlethumb Brooks is an internationally renowned artist suffering a life of great tragedy. While the world knows Littlethumb as a famous painter, he secretly moonlights as the operational force behind his uncle's globetrotting team of soldiers of fortune, the Electric Medicine Men.

When Littlethumb's most famous collection of paintings, The Marias, is stolen, it's up to the Electric Medicine Men to recover them. Along the way the team discovers a world-changing invention, a villainous syndicate marches toward global upheaval, and a disturbed journalist unleashes his misguided wrath on our hero.

Navigating all of this madness, Littlethumb's greatest challenge is conquering the fear he'll never be able to safely raise his daughter.