Art, Science, and Technology of Pharmaceutical Compounding, (The) 5th Edition

The Art, Science, and Technology of Pharmaceutical Compounding presents in a logical and progressive format all the information that pharmacists and student pharmacists need to understand the purpose and processes of compounding. Author Loyd V. Allen Jr., the preeminent expert, covers basic guidelines, economic and technical factors that compounding pharmacists must consider, and all aspects of good manufacturing practices for compounded medications. In this fifth edition, all chapters have been updated and several significantly revised—particularly “Compounding with Hazardous Drugs”—and three new chapters have been added: “Pharmaceutical Compounding Errors,” “Foams,” and “Compounding with Special Ingredients.” Information on the new law affecting compounding, the Drug Quality and Security Act, is incorporated throughout the book. Chapter 14 now includes information on compounding "films."

KEY FEATURES:

· The initial chapters describe the requisite facilities and equipment, record keeping, calculations, and quality control.

· Three new chapters: “Pharmaceutical Compounding Errors,” “Foams,” and “Compounding with Special Ingredients.”

· Fifteen chapters are devoted to the compounding of each dosage form in turn, from powders and granules to injectables.

· Additional chapters cover veterinary compounding, compounding for special populations, compounding for specific procedures, compounding for clinical studies, compounding cosmetics, compounding with hazardous drugs, and compounding in the event of a natural disaster or terrorist attack.

· Nine appendices provide essential information on the compounding process and examples of standard operating procedures.

· The necessary ingredients and steps are listed for compounding more than 200 sample formulations, including bases, vehicles, and ingredient-specific preparations.

· Updated throughout, including information on the new Drug Quality and Security Act.

AUDIENCE:

Student Pharmacists

Pharmacists who compound medications for patients in community, hospital, and other practice settings

TABLE OF CONTENTS:

Preface

Introduction

Abbreviations and Approximate Solubility Descriptors

1. Guidelines for Compounding Practices

2. Compounding Ingredient Considerations

3. Compounding with Hazardous Drugs

4. Facilities, Equipment, and Supplies

5. Records and Record Keeping

6. Stability of Compounded Preparations

7. Pharmaceutical Compounding Calculations

8. Quality Control

9. Flavors, Sweeteners, and Colors

10. Preservation, Sterilization, and Depyrogenation

11. Powders and Granules

12. Capsules

13. Tablets

14. Lozenges/Troches and Films

15. Suppositories and Inserts

16. Sticks

17. Solutions

18. Suspensions

19. Emulsions

20. Foams

21. Ointments, Creams, and Pastes

22. Gels

23. Ophthalmic, Otic, and Nasal Preparations

24. Inhalation Preparations

25. Parenteral Preparations

26. Biotechnology, Nanotechnology, and Pharmacogenomics

27. Special Populations and Preparations

28. Compounding with Special Ingredients

29. Veterinary Pharmaceuticals

30. Compounding for Clinical Studies

31. Cosmetics for Special Populations and for Use as Vehicles

32. Compounding for Terrorist Attacks and Natural Disasters

33. Pharmaceutical Compounding Errors

Appendix I – Drugs and Dosage Forms Not to be Compounded (The FDA Negative List)

Appendix II – Standard Operating Procedures

Appendix III – Specific Gravity Values of Selected Liquids

Appendix IV – Using Weight-Related Conversion Factors

Appendix V – Sodium Chloride Equivalent Values of Selected Agents

Appendix VI – Buffers and Buffer Solutions

Appendix VII – Allowable Endotoxin Levels in Parenteral Preparations

Appendix VIII – Viscosity-Increasing Agents for Aqueous and Nonaqueous Systems

Appendix IX – Disinfecting Agents Used in Compounding Pharmacies

Index