On the cusp of pot legalization in California, Jerry runs afoul of some San Francisco bikers in the marijuana game. He flees straight up Highway 101 to Humboldt County to hide out deep in the hills at Vic's, a reclusive pot farmer and old pal of his tough-as-nails mother. But trouble finds Jerry no matter where he goes and soon the bikers, a pair of stone killers, and a Russian weed tycoon named Vlad the Inhaler are all hot on Jerry's trail.

Fallout from the unfolding chaos piques the interest of SFPD detective, Roland Mackie, when he learns Jerry's host, Vic, is somehow involved. It opens a twenty-year-old wound, an unsolved case called the Fulton Street Massacre, and Mackie is willing to do whatever it takes to get a pair of cuffs on the elusive Vic.

When Jerry and his protectors are chased off the mountain and back down the 101 to an inevitable showdown back in the Bay, he learns Vic is much more than his host, he's a mentor, his mother's hero, and the toughest man he's ever met.

With an unforgettable cast of characters and an action-packed plot, 101 is a wild ride through Northern California's "emerald triangle."