Something unusual is going on with the dementia patients at Pleasant View Nursing Home.

Dr. Jim Bob Brady, Houston orthopedic surgeon and amateur sleuth, finds himself in the midst of a different type of medical mystery. His friend and colleague, Dr. James Morgenstern, refers him a series of dementia patients with orthopedic problems from Pleasant View Nursing Home. Each patient dies, irrespective of the treatment, a situation that Doc Brady is unaccustomed to.

Each death prompts an autopsy, performed by another Brady colleague, Dr. Jeff Clarke, who discovers unusual brain pathology in each patient. Some of the tissue samples show nerve regeneration, a finding unheard of in dementia patients.

Doc Brady, enraged by the loss of his patients and obsessively curious about the pathologic findings, begins to investigate the nursing home, as well as its owner and CEO, Dr. Theodore Frazier. This leads Brady and Clarke on an adventure to discover the happenings at Pleasant View—an adventure that sees them running for their lives.