Can a person change so profoundly that they become someone entirely new? Or will they always be the person whom they were?

These questions lie at the heart of this techno thriller and locked room murder mystery. A pioneering biomedical company believes that they have cured five imprisoned serial killers using a resurrected medical procedure, the amygdalotomy, and the company avers before a federal court that the prisoners are now fundamentally new people. Therefore the court releases the prisoners, and the biomedical company flies them and their own staff to a luxurious hotel in Alaska for a celebration and a public relations event.

But Daniel Larch, the CEO of the company, is having trouble. Larch’s adult stepson catches him having an affair with the company lawyer, the Russians are trying to buy Larch out, and an aggrieved relative of one of the serial killers’ victims appears unexpectedly at The Endicott Hotel.

A blizzard strikes, communications are cut off, and Daniel Larch is poisoned to death. The biomedical company staff find themselves trapped in the hotel with five former serial killers. Walter Churchfield, a former detective, steps in to restore order. But as more guests are killed, Churchfield has to decide whether one of the serial killers is committing the murders, or whether the killer is someone who might never have been caught killing before.