Tranquil life in a Tuscan villa and vineyard ends abruptly as a malevolent plot unfolds, targeting regional vintners. Caught in the crossfire are diverse international guests, each seeking solitude for personal reasons.

Erik Swanson, a crime reporter, hopes to leave his emotional demons behind in America and find a muse to inspire a book. Iliana, a beautiful cellist, seeks respite from both her hectic orchestra schedule and an abusive relationship. Maria, the owner of the villa and vineyard, is mourning the unexpected death of her husband while striving to maintain a robust enterprise. Dieter, a quarrelsome climate scientist from Heidelberg, pursues time to sharpen his lectures and manuscripts to convince nonbelievers.

The guests' ideas often clash with the challenging social forces emerging in Italy, but some share their surprising talents to assist a local police inspector in addressing the nefarious plot—though at life-altering costs to all at the villa.