“In the United States, we have some of the world's most advanced medical technology, highly specialized care, and world-class emergency services. At the same time, the system is inefficient, inequitable, and unsatisfying to nearly everyone who interacts with it. My friend Marschall Runge offers a compelling prescription for disruption. With four decades of experience―much of it at the very top of academic medicine―his insights are not only well-informed but well worth our attention.”

― Sanjay Gupta, MD

Associate Chief of Neurosurgery, Grady Memorial Hospital; Associate Professor of Neurosurgery, Emory University School of Medicine; Chief Medical Correspondent, CNN; bestselling author and host of Chasing Life podcast

“Dr. Marschall Runge delivers a bold and visionary roadmap for transforming American healthcare. With clarity and conviction, he explores how emerging technologies can revolutionize care―making it more affordable, equitable, and effective for all. But this is more than a call for innovation―it is a call for accountability. Dr. Runge challenges us to ask who truly benefits from progress, who is being left behind, and what courageous leadership must look like in this era of unprecedented disruption. This is a vital and timely contribution to the urgent conversation about the future of medicine―and what it must become to serve society in the 21st century.”

― Victor J. Dzau, MD

President, National Academy of Medicine; Chancellor Emeritus, Duke University Health System

“In a pivotal era marked by entrepreneurship, innovation, and significant change in healthcare, Dr. Marschall Runge, a physician and healthcare leader, stands out as a seasoned voice in American medicine, speaking with both candor and courage. The Great Healthcare Disruption serves as a masterclass in leadership, exposing the systemic failures of our healthcare system, while presenting pragmatic solutions for reinvention. This book is not merely an academic text; it's a comprehensive blueprint for the bold transformation our nation urgently needs.”

― Michael M.E. Johns, MD

Executive Vice President for Health Affairs Emeritus, Emory University; Founding CEO Emory Healthcare; Former Dean, Johns Hopkins School of Medicine

“The American healthcare landscape is undergoing drastic changes, some of which are necessary, while others are problematic. Dr. Marschall Runge, who has led one of the leading US health systems and medical schools, is in a perfect position―and comes through―with an exceptionally thoughtful and thorough analysis, along with proposing solutions and policy changes.”

― Eric Topol, MD

Professor and EVP, Scripps Research; Founder and Director, SRTI

“In The Great Healthcare Disruption, Dr. Marschall Runge provides both a compelling case and detailed plan for the reimagination of healthcare. He is as practical as he is inspirational, calling upon leaders to follow a roadmap designed to make care more customer focused―easy to access, affordable, and rooted in prevention. As a fellow healthcare leader who also believes in the urgent need for industry transformation, I deeply appreciate Dr. Runge’s bold vision and dedication to fixing what is broken.”

― Pete McCanna

CEO, Baylor Scott & White Health

“Health care is arguably moving faster than at any time since the era of vaccines and antibiotics a century ago. Runge hits the most important disruptors―AI, retail medicine, GLP-1 agonists, personalized therapies―with the rigor and relatability uniquely brought by a physician and scientific leader. In addition to insightful reviews of each, he lays out how these innovations relate to and accelerate one another. While acknowledging the potential risks, Runge presents a compelling vision by which we move past the stagnant, expensive, and often underperforming health care system of today.”

― John Birkmeyer, MD

President, Sound Physicians; Professor (adjunct), Dartmouth Institute for Health Policy and Clinical Practice

“The Great Healthcare Disruption is a must-read for all who are passionate about improving healthcare and health outcomes in a financially sustainable way. Dr. Runge provides practical perspectives as an experienced clinician and prominent executive on one of the most important challenges facing the United States. Against a backdrop of challenging consumer expectations for unlimited care and access, Dr. Runge discusses the significant challenges across key sectors of the U.S. healthcare system from a global perspective. He highlights the ethical and financial dilemmas for access to care and breakthrough therapies and drugs. Dr. Runge offers a future-forward roadmap and thought-provoking prescriptions for improving health outcomes while reducing healthcare costs.”

― Mark Hussey

CEO and President, Huron Consulting

"I loved the fact that the book summarizes Dr. Runge’s assertions with ‘The Takeaway’, which provided a time to reflect... [I] hope and pray we can realize the need to collectively focus our resources on the many topics that Dr. Runge raised… merging mental health with primary care; using AI to address scarcity and access issues; and a focus on genetic medicine. Seemingly obvious, but not yet tackled in our healthcare delivery system."

― Stephanie L. Reel

Former CIO, Johns Hopkins Medicine, Johns Hopkins Health System, and Johns Hopkins University