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Blood Ops leader Dr. O is chained in the bowels of Steele City, the state’s maximum security prison, and the clock is ticking for Nina and Frankie to bust him out. Now that supernatural creatures are out of the closet, Providence is descending into an apocalyptic wasteland. With the abrupt shut down Blood Ops, Nina and Frankie are forced to rely on questionable allies to battle Leila, a powerful witch/vampire hybrid hell bent on creating an indestructible supernatural army. She also happens to be Nina’s mom. Alliances are tested and relationships fractured as Nina and her band of supernatural crime fighting misfits are pushed to the breaking point.