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Replaceable You

Adventures in Human Anatomy

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Pub Date Sep 16 2025 | Archive Date Aug 31 2025

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Description

From the New York Times best-selling author of Stiff and Fuzz, a rollicking exploration of the quest to re-create the impossible complexities of human anatomy.

The body is the most complex machine in the world, and the only one for which you cannot get a replacement part from the manufacturer. For centuries, medicine has reached for what’s available—sculpting noses from brass, borrowing skin from frogs and hearts from pigs, crafting eye parts from jet canopies and breasts from petroleum by-products. Today we’re attempting to grow body parts from scratch using stem cells and 3D printers. How are we doing? Are we there yet?

In Replaceable You, Mary Roach explores the remarkable advances and difficult questions prompted by the human body’s failings. When and how does a person decide they’d be better off with a prosthetic than their existing limb? Can a donated heart be made to beat forever? Can an intestine provide a workable substitute for a vagina?

Roach dives in with her characteristic verve and infectious wit. Her travels take her to the OR at a legendary burn unit in Boston, a “superclean” xeno-pigsty in China, and a stem cell “hair nursery” in the San Diego tech hub. She talks with researchers and surgeons, amputees and ostomates, printers of kidneys and designers of wearable organs. She spends time in a working iron lung from the 1950s, stays up all night with recovery techs as they disassemble and reassemble a tissue donor, and travels across Mongolia with the cataract surgeons of Orbis International.

Irrepressible and accessible, Replaceable You immerses readers in the wondrous, improbable, and surreal quest to build a new you.

About the Author: Mary Roach is the author of seven best-selling works of nonfiction, including Grunt, Stiff, and, most recently, Fuzz. Her writing has appeared in National Geographic and the New York Times Magazine, among other publications. 

From the New York Times best-selling author of Stiff and Fuzz, a rollicking exploration of the quest to re-create the impossible complexities of human anatomy.

The body is the most complex machine in...


A Note From the Publisher

LibraryReads votes due by 8/1/25.

LibraryReads votes due by 8/1/25.


Advance Praise

"We are all replaceable to some degree or another . . . with the exception of Mary Roach. There is no one and nothing like her—singular, bizarre, dedicated, passionate, fascinating. Her writing traffics at the unusual intersection of science, storytelling, and humor. That is a very tricky intersection to navigate, and no one does it as masterfully or consistently as she. I devour everything she writes." -Jason Alexander, actor/director

"Mary Roach has had a more direct impact on my career than any other writer. She is her own genre of book—gonzo, hilarious, wildly educational. This is Roach at her finest." -Daniel Kraus, author of Whale Fall

"In her brilliant (and brilliantly funny book) Replaceable You, Mary Roach explores the puzzle of the human body, the way we can assemble and reassemble the very human pieces into different versions of who we are and how we work. The result is intriguing, compassionate, wise and—as with all her books—addictively readable. Or to put this another way: Don't miss it." -Deborah Blum, best-selling author of The Poisoner’s Handbook

"We are all replaceable to some degree or another . . . with the exception of Mary Roach. There is no one and nothing like her—singular, bizarre, dedicated, passionate, fascinating. Her writing...


Available Editions

EDITION Hardcover
ISBN 9781324050629
PRICE $28.99 (USD)
PAGES 288

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Featured Reviews

I adore Mary Roach--I will learn whatever she's trying to teach us. This time, it's how doctors and scientists use artificial body parts to replace when their original counterparts malfunction or are irreparably injured. Yes, this is technically a medicine/science book, but, as with all of Roach's work, you could shelve it in the humor section as well. I learned, among other things, that the doctor she was looking to contact in one chapter was the man she lost her virginity to in college and that Mitch McConnell's facial structure may make it harder for him to be intubated.

If you want to learn a new subject but don't want to pick up a dense, textbook-like tome, Mary Roach's books may be for you.

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There is something delightful about settling in to a Mary Roach primer - you feel a bit stupid about everything you don't know but her nonjudgmental writing will have you feeling like an expert by the end and ready to share tidbits with anyone who will listen. Her natural curiosity, easy going writing style (similar to Bill Bryson) and lighthearted banter is infectious. The human body and science can get a bit heavy but with injections of laughter at some of the more absurd concepts and history make the medicine go down easier. Everything you ever wanted to know (or didn't have a clue it even existed) about the human body and failing parts that need replacement can be found here. From the history of dentures, prosthetic noses to the fascinating advancement in cell regeneration and new materials - it is one interesting ride. This is the perfect book to put into the hands of readers who typically do not enjoy non-fiction. My thanks to the publisher for the advance copy.

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Mary Roach has the most uniquely curious mind I have ever come across. There is no lengths she is unwilling to go to learn about the subject the has captured her attention. In doing so she takes us on a journey into the cutting edge world of medical innovation.

So much ground was covered here. The book began with how early dentures were made. Roach then moved on to burn victims and potential types of skin transplants for them. One example was a transplant from frog skins while another was a biobandaide from farmed fish waste.

As she looked at our lungs she had to try sleeping in an iron lung machine because, why not? The ECMO machine was the most fascinating thing to me. It allows blood to be oxygenated outside of the body, as opposed to using your lungs. In addition there were Pluripotent cells, hypo immune cells, gene editing, 3D bioprinters, sphincter replacements and a fun chapter on harvesting body parts.

Roach has a dark wit that that was hard to resist. Liposuction reminded Mary Roach of a raspberry smoothie and made her hungry. In another procedure she compared a body part to tamales. Using self deprecating humor she described her ideal Spotify playlist for organ retrieval with “Spirits in the Sky” and “Only the Good Die Young” hitting her top spots.

I was thoroughly intrigued and excited by the science while captivated by the author herself. This sophisticated, state of the art science was described in layman’s terms. An enjoyable read and one I highly recommend. 5 stars.

I would like to thank NetGalley and the publishers for an advance copy of this fantastic book. These opinions are my own.

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Mary Roach gets an auto-add to my TBR with every publication, and she never disappoints me. This time she tackles a subject that revisits some parts of her previous books and adds to them. How replaceable is the human body? She wrote Stiff, about human cadavers, in 2003; Bonk, about sex, in 2008 and Gulp, about the digestive system, in 2013. In medical terms, even 12 years ago was the Bronze Age. There have been so many advancements since she wrote about the human body, that you’d think “Replaceable You” would be about all the ways that we can upgrade ourselves. Well, read this and be surprised. Roach writes about the most complicated technical and scientific issues in a way that even I can understand. Her sense of humor made me laugh so much that my husband was surprised when he found out that I was reading about heart failure. She makes readers feel like they’re there with her, making her interviewees (and even some dead people) feel approachable. There is a bit about animal experimentation that I had to skip (that’s my one and only trigger); and some other parts require a strong stomach. As with all of Roach’s books, this is not for everyone, but curious readers will love how she asks the questions that we’re all asking and some that we hadn’t even considered. I’ll keep praying for a way to restore my old-age vision so that I can keep reading her books forever.
I chose to read this book and all opinions in this review are my own and completely unbiased. Thank you, NetGalley/W. W. Norton & Company.

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Life is good when there’s a new Mary Roach book to absorb. My favorite entertaining science writer is back with a book about the various attempts to replicate parts of the body and its various functions, from joint replacements to hair transplants and much more. In the service of exploring the subject, she travels as far as Mongolia and goes so far as to try out an iron lung. I think this book had fewer total laugh-out-loud moments than some of her previous books, and it’s a less “weird” subject than some she has explored (e.g., death), but it still filled with riveting tales of quirky corners of science. and buoyed by her endless curiosity…and as usual for a Mary Roach book, the footnotes and acknowledgments are no less entertaining than the rest. Anyone who loves Mary Roach is in for another good ride with this book (and will yearn to be a scientist, if only to be trailed and then written about by her), and anyone who doesn’t love Mary Roach had better get started on reading her books.

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Mary Roach scores another one for science with a side of comedy. This time she turns her searching gaze toward replacement parts for the human body. I really enjoyed this one, as it gives readers a grand tour of the latest biotechnology and science while provoking contemplation on moral dilemmas such as "At what point are we just playing God?" Roach's trademark humor sparkles throughout, making even the footnotes, ordinarily the domain of dry academic citation, must-read material. I highly recommend it, with thanks to the publisher for the complimentary advance NetGalley.

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