If you were offered a chance to cure your child's disease, would you take it? The Willow family have been through a lot together. Louise has devoted her life to her family and raising her disabled daughter, Patience. Pete now works abroad, determined to provide more, even if it means seeing less of those he loves. And Eliza, in the shadow of her sister, has a 'perfect' life in London, striving to live up to her mother's high standards.
Meanwhile, Patience lives her life quietly, watching and judging the world while she's trapped in her own body. She laughs, she cries, she knows what she wants, but she can't ever communicate this to those who make the decisions for her. Patience only wants a voice, but this is impossible.
When the opportunity to put Patience into a new gene therapy trial to cure her Rett syndrome becomes available, opinions are divided. The stakes are high, and the Willow family face an almost impossible dilemma. 
And what is a 'normal life,' anyway? Is Patience about to find out...?